Dr. Sean Hill is the co-founder and Chief Executive Officer (CEO) of Senscience, a company advancing open, AI-ready, and context-rich data infrastructure to accelerate scientific discovery. He is also co-founder and Chief Science Officer (CSO) of Kelello Health, a digital platform transforming the delivery of measurement-based mental health care.
Dr. Hill is a Professor in the Departments of Psychiatry and Physiology at the University of Toronto and a Collaborating Scientist at the Centre for Addiction and Mental Health (CAMH) in Toronto, Canada. He is also Titular Professor at the École polytechnique fédérale de Lausanne (EPFL), Switzerland. From 2018 to 2023, he served as the inaugural Director of the Krembil Centre for Neuroinformatics at CAMH, where he led the application of data science, artificial intelligence, and multi-scale computational modeling to improve the diagnosis, prediction, and treatment of brain disorders.
Dr. Hill completed his Ph.D. in computational neuroscience at the Université de Lausanne and pursued postdoctoral research at The Neurosciences Institute in La Jolla, California, and the University of Wisconsin–Madison. He subsequently joined the Computational Biology group at IBM Research.
He has served as co-director of the Blue Brain Project, leading its Neuroinformatics division, and directed the neuroinformatics strategy and platform development for the Human Brain Project (2013–2016). Additionally, Dr. Hill was Executive Director (2011–2013) and Scientific Director (2014–2016) of the International Neuroinformatics Coordinating Facility at the Karolinska Institutet in Stockholm, Sweden.
Dr. Hill has extensive experience in large-scale data integration and in building and simulating biophysically detailed models of brain circuitry. His research focuses on the cellular basis of brain states within thalamocortical circuitry, developing numerous large-scale models of cortical and corticothalamic systems during wakefulness, sleep, and anesthetic conditions, contributing to the understanding of the cellular and synaptic mechanisms underlying diverse brain states.
Work
University of Toronto
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Professor
Canada
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Centre for Addiction and Mental Health
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Scientific Director
Canada
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École Polytechnique Fédérale de Lausanne
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co-Director
Switzerland
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Publications
Challenges for Multi-scale Modeling Languages
journal-article
“The Blue Brain Project”
conference-paper
“The Blue Brain Project”
conference-paper
Sleep improves the variability of motor performance
journal-article
The Blue Brain Project: building the neocortical column
journal-article
Reduced sleep in Drosophila Shaker mutants
journal-article
OMNI: Towards a comprehensive object model for neuroinformatics
journal-article
Combinatorial expression rules of ion channel genes in juvenile Rat (rattus norvegicus) neocortical neurons
PLoS ONE
journal-article
A neuron membrane mesh representation for visualization of electrophysiological simulations
IEEE Transactions on Visualization and Computer Graphics
journal-article
Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits
Proceedings of the National Academy of Sciences of the United States of America
journal-article
Intrinsic morphological diversity of thick-tufted layer 5 pyramidal neurons ensures robust and invariant properties of in silico synaptic connections
Journal of Physiology
journal-article
Channelpedia: An Integrative and Interactive Database for Ion Channels
journal-article
Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties
PLoS Computational Biology
journal-article
Effective stimuli for constructing reliable neuron models
PLoS Computational Biology
journal-article
Modeling the effects of midazolam on cortical and thalamic neurons
Neuroscience Letters
journal-article
Breakdown of effective connectivity during slow wave sleep: Investigating the mechanism underlying a cortical gate using large-scale modeling
Journal of Neurophysiology
journal-article
Modeling the gabaergic action of etomidate on the thalamocortical system
Anesthesia and Analgesia
journal-article
Network-related challenges and insights from neuroscience
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
journal-article
Evaluating automated parameter constraining procedures of neuron models by experimental and surrogate data
Biological Cybernetics
journal-article
Identifying, tabulating, and analyzing contacts between branched neuron morphologies
IBM Journal of Research and Development
journal-article
Sleep improves the variability of motor performance
Brain Research Bulletin
journal-article
Sleep homeostasis and cortical synchronization: I. Modeling the effects of synaptic strength on sleep slow waves
Sleep
journal-article
Reduced sleep in Drosophila Shaker mutants
Nature
journal-article
Modeling the effects of transcranial magnetic stimulation on cortical circuits
Journal of Neurophysiology
journal-article
Modeling sleep and wakefulness in the thalamocortical system
Journal of Neurophysiology
journal-article
The sleep slow oscillation as a traveling wave
Journal of Neuroscience
journal-article
Sleep homeostasis in Drosophila melanogaster
Sleep
journal-article
Dynamic transitions in global network activity influenced by the balance of excitation and inhibition
Network: Computation in Neural Systems
journal-article
Dynamic transitions in global network activity influenced by the balance of excitation and inhibition