Sean Hill

About

Dr. Sean Hill is the co-founder and Chief Executive Officer (CEO) of Senscience, a company advancing open, AI-ready, and context-rich data infrastructure to accelerate scientific discovery. He is also co-founder and Chief Science Officer (CSO) of Kelello Health, a digital platform transforming the delivery of measurement-based mental health care. Dr. Hill is a Professor in the Departments of Psychiatry and Physiology at the University of Toronto and a Collaborating Scientist at the Centre for Addiction and Mental Health (CAMH) in Toronto, Canada. He is also Titular Professor at the École polytechnique fédérale de Lausanne (EPFL), Switzerland. From 2018 to 2023, he served as the inaugural Director of the Krembil Centre for Neuroinformatics at CAMH, where he led the application of data science, artificial intelligence, and multi-scale computational modeling to improve the diagnosis, prediction, and treatment of brain disorders. Dr. Hill completed his Ph.D. in computational neuroscience at the Université de Lausanne and pursued postdoctoral research at The Neurosciences Institute in La Jolla, California, and the University of Wisconsin–Madison. He subsequently joined the Computational Biology group at IBM Research. He has served as co-director of the Blue Brain Project, leading its Neuroinformatics division, and directed the neuroinformatics strategy and platform development for the Human Brain Project (2013–2016). Additionally, Dr. Hill was Executive Director (2011–2013) and Scientific Director (2014–2016) of the International Neuroinformatics Coordinating Facility at the Karolinska Institutet in Stockholm, Sweden. Dr. Hill has extensive experience in large-scale data integration and in building and simulating biophysically detailed models of brain circuitry. His research focuses on the cellular basis of brain states within thalamocortical circuitry, developing numerous large-scale models of cortical and corticothalamic systems during wakefulness, sleep, and anesthetic conditions, contributing to the understanding of the cellular and synaptic mechanisms underlying diverse brain states.

Work

University of Toronto

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Professor

Canada

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Centre for Addiction and Mental Health

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Scientific Director

Canada

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École Polytechnique Fédérale de Lausanne

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co-Director

Switzerland

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Publications

Challenges for Multi-scale Modeling Languages

journal-article

“The Blue Brain Project”

conference-paper

“The Blue Brain Project”

conference-paper

Sleep improves the variability of motor performance

journal-article

The Blue Brain Project: building the neocortical column

journal-article

Reduced sleep in Drosophila Shaker mutants

journal-article

OMNI: Towards a comprehensive object model for neuroinformatics

journal-article

Combinatorial expression rules of ion channel genes in juvenile Rat (rattus norvegicus) neocortical neurons

PLoS ONE

journal-article

A neuron membrane mesh representation for visualization of electrophysiological simulations

IEEE Transactions on Visualization and Computer Graphics

journal-article

Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits

Proceedings of the National Academy of Sciences of the United States of America

journal-article

Intrinsic morphological diversity of thick-tufted layer 5 pyramidal neurons ensures robust and invariant properties of in silico synaptic connections

Journal of Physiology

journal-article

Channelpedia: An Integrative and Interactive Database for Ion Channels

journal-article

Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

PLoS Computational Biology

journal-article

Effective stimuli for constructing reliable neuron models

PLoS Computational Biology

journal-article

Modeling the effects of midazolam on cortical and thalamic neurons

Neuroscience Letters

journal-article

Breakdown of effective connectivity during slow wave sleep: Investigating the mechanism underlying a cortical gate using large-scale modeling

Journal of Neurophysiology

journal-article

Modeling the gabaergic action of etomidate on the thalamocortical system

Anesthesia and Analgesia

journal-article

Network-related challenges and insights from neuroscience

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

journal-article

Evaluating automated parameter constraining procedures of neuron models by experimental and surrogate data

Biological Cybernetics

journal-article

Identifying, tabulating, and analyzing contacts between branched neuron morphologies

IBM Journal of Research and Development

journal-article

Sleep improves the variability of motor performance

Brain Research Bulletin

journal-article

Sleep homeostasis and cortical synchronization: I. Modeling the effects of synaptic strength on sleep slow waves

Sleep

journal-article

Reduced sleep in Drosophila Shaker mutants

Nature

journal-article

Modeling the effects of transcranial magnetic stimulation on cortical circuits

Journal of Neurophysiology

journal-article

Modeling sleep and wakefulness in the thalamocortical system

Journal of Neurophysiology

journal-article

The sleep slow oscillation as a traveling wave

Journal of Neuroscience

journal-article

Sleep homeostasis in Drosophila melanogaster

Sleep

journal-article

Dynamic transitions in global network activity influenced by the balance of excitation and inhibition

Network: Computation in Neural Systems

journal-article

Dynamic transitions in global network activity influenced by the balance of excitation and inhibition

journal-article

Sean Hill